DETROIT -- Matthew Stafford threw a go-ahead, 18-yard touchdown pass to Anquan Boldin with 16 seconds left.
The Lions (4-3) extended their winning streak to three games. The Redskins (4-3) had won four straight.
Stafford, who set up game-winning kicks in the previous two games, led his team to another win in the 100th game of his career. He was 18 of 29 for 266 yards, one TD and no turnovers.
Kirk Cousins scored a go-ahead TD on a 19-yard run with 1:05 left (see full recap).
4 interceptions power Giants past Rams in London
LONDON -- The Giants capitalized on four interceptions of Case Keenum in the first NFL game played at London's home of English rugby, a sold-out and raucous Twickenham Stadium.
Keenum, coming off the best start of his career, had the Rams at the Giants' 15-yard line with 50 seconds left when he lobbed a pass in the left corner of the end zone that Dominique Rodgers-Cromartie easily picked off. Keenum's intended target, Brian Quick, failed to get the quarterback's audible and cut off his route early.
Keenum, who finished 32 of 53 for 291 yards and one touchdown, has thrown an interception on the Rams' final offensive play of the last three games. That likely will fuel debate on a potential quarterback change to overall No. 1 draft pick Jared Goff.
Landon Collins returned his first of two picks 44 yards for a second-quarter touchdown, and Dominique Rodgers-Cromartie also had two interceptions (see full recap).
Seahawks, Cardinals play to ugly 6-6 tie
GLENDALE, Ariz. -- Seattle's Stephen Hauschka and Arizona's Chandler Catanzaro missed short field goals that would have won it in overtime and the Seahawks and Cardinals tied 6-6 on Sunday night.
Hauschka's 27-yard field goal was wide left with seven seconds left after Catanzaro's 24-yarder bounced off the left upright.
The last tie in the NFL came in 2014, when Carolina and Cincinnati tied 37-37. The tie was the Cardinals' first since Dec. 7, 1986, a 10-10 draw at Philadelphia when the franchise was based in St. Louis. It was the first for the Seattle since entering the NFL in 1976.
The Cardinals (3-3-1) dominated the game statistically and looked to be in shape to win it after Carson Palmer's 40-yard pass to J.J. Nelson set up Catanzaro's short kick.
The Seahawks (4-1-1), stuffed throughout regulation by the Arizona defense, took over and Russell Wilson completed passes of 31 yards to Jermaine Kearse and 27 yards to Doug Baldwin to give Houschka his short attempt. Both kickers made field goals on their teams' first possession of overtime.
Catanzaro, who kicked field goals of 46 and 45 yards, also had a 39-yard field goal blocked by a stunning play by Bobby Wagner when he hurdled Arizona long snapper Aaron Brewer.
Cardinals coach Bruce Arians argued loudly for a penalty and was charged with a timeout when he challenged a play that is not reviewable. That proved significant when the Cardinals couldn't stop the clock to get off a short field goal attempt as the first half ended (see full recap).
Fitzpatrick relieves Smith, propels Jets to comeback win over Ravens
EAST RUTHERFORD, N.J. -- Ryan Fitzpatrick replaced an injured Geno Smith and led the Jets on three scoring drives, and a rejuvenated defense came up with two rare interceptions.
Fitzpatrick came in for Smith in the second quarter and led the Jets on a go-ahead drive capped by a 13-yard touchdown catch by Matt Forte. Fitzpatrick finished 9 of 14 for 120 yards and a touchdown as the Jets (2-5) snapped a four-game losing streak.
Smith injured his right knee while taking a sack from Baltimore's Matthew Judon. Fitzpatrick was efficient after losing his job earlier in the week.
Joe Flacco started for Baltimore (3-4), loser of four in a row, after being questionable with a sore shoulder. He went a team-record 176 consecutive throws without an interception before Buster Skrine picked off his pass in the third quarter (see full recap).
Ajayi rushes for 200 yards in second straight game as Dolphins top Bills
MIAMI GARDENS, Fla. -- Jay Ajayi tied an NFL record by surpassing 200 yards rushing for the second game in a row. Ajayi rushed for 214 yards in 29 carries after totaling 204 yards a week earlier in a win over Pittsburgh. He scored on a 4-yard run, and busted a 53-yarder when the Dolphins were pinned at their 3 and trailing in the fourth quarter.
The Dolphins (3-4) used an extra lineman much of the time to clear big holes for Ajayi, who tied the NFL record for consecutive 200-yard games held by O.J. Simpson, Earl Campbell and Ricky Williams.
Miami overcame an 11-point deficit with 16 minutes left to end a four-game winning streak by the Bills (4-3) and beat them for only the second time in their past seven meetings.
Buffalo RB LeSean McCoy, ranked second in the NFL in rushing, started, but totaled only 11 yards in eight carries before departing with a hamstring problem (see full recap).
Luck improves to 8-0 vs. Titans in Colts' 34-26 win
NASHVILLE, Tenn. -- Andrew Luck threw a 7-yard touchdown pass to Jack Doyle with 1:55 left to put Indianapolis ahead to stay, and the Colts rallied to beat the Titans for their 10th straight win against their AFC South rival.
The Colts (3-4) came in having lost two of three, including blowing a 14-point lead in an overtime loss last week at Houston. But Luck he improved to 8-0 against the Titans with yet another comeback win. He finished with 353 yards passing and three TDs, the last after Tennessee went up 23-20.
T.Y. Hilton caught seven passes for 133 yards, including a 37-yard TD. The Colts shook off 12 penalties for 131 yards in pulling out their 15th win in 16 games against Tennessee.
The Titans (3-4) saw their two-game winning string end.
Colts kicker Adam Vinatieri kicked a pair of field goals, and the second, a 33-yarder with 3:46 left in the third quarter gave him an NFL record 43 consecutive field goals made (see full recap).
Patriots prove to be too much for Roethlisberger-less Steelers
PITTSBURGH -- LeGarrette Blount ran for 127 yards and two scores while Tom Brady completed 19 of 26 passes for 222 yards and two touchdowns.
Steelers quarterback Landry Jones played capably while filling in for Roethlisberger, who watched from the sideline after undergoing left knee surgery last week.
Making his third career start, Jones threw for 281 yards with a touchdown and an interception. But undermanned Pittsburgh (4-3) lost its second straight when its defense failed to keep Brady under wraps.
New England (6-1) remained perfect since Brady returned from his four-game "Deflategate" suspension, emphatically responding to a push by the Steelers with a pair of second-half touchdowns. Brady improved to 9-2 against the Steelers, throwing for 26 touchdowns and three interceptions (see full recap).
Chargers rally from 17 down to earn OT win over Falcons
ATLANTA -- Josh Lambo's 42-yard field goal in overtime gave San Diego its first road win of the year as the Chargers rallied from a 17-point deficit.
The Chargers (3-4) trailed 27-10 in the second quarter. They had lost 11 of their past 12 road games.
Linebacker Denzel Perryman delivered two key plays late in the game. Perryman's interception of Matt Ryan's pass for Julio Jones set up Lambo's tying 33-yard field goal with 18 seconds remaining in regulation.
Perryman's fourth-and-1 stop on running back Devonta Freeman gave San Diego the ball at Atlanta's 43 for the Chargers' winning drive. Perryman grabbed Freeman's feet behind the line for the key tackle on the Falcons' gamble (see full recap).