The Sixers (7-12) will look to end their struggles on the road when they travel to face the Charlotte Bobcats (8-11).
Tipoff is set for 7 p.m. (CSN) at Time Warner Cable Arena.
Let's take a closer look at the matchup:
1. Missing the young guns
The Sixers will be without one of their most potent weapons when they take the court on Friday night.
Michael Carter-Williams did not make the trip with the team and will miss the game because of a sore right knee. The rookie point guard suffered the injury during the Sixers' loss to the Detroit Pistons last Sunday.
Carter-Williams' absence will certainly create a void on the stat sheet. He is coming off his first career triple-double in Tuesday's 126-125 win over the Orlando Magic in double overtime. MCW is averaging 17.7 points, 7.3 assists and 5.3 rebounds per game so far this season.
The Sixers won't be the only one missing a young playmaker. The Bobcats won't have second-year forward Michael Kidd-Gilchrist, who suffered a fractured left hand on Tuesday against the Dallas Mavericks and will miss four to six weeks.
Kidd-Gilchrist is averaging 9.1 points and 5.3 rebounds per game this season while shooting 50 percent from the field.
2. Road to nowhere
Things started off beautifully for the Sixers on the road this season. They rallied from down double-digits to pull off a comeback win in Washington for their second victory of the season.
Since that point, things have been all downhill for the Sixers away from home. They've lost seven straight road games with four of those defeats coming by double digits.
Breaking that skid won't necessarily be easy against the Bobcats. They are 4-6 at home this year and sit just above the Sixers in the Eastern Conference standings.
3. Opposites attract
Friday night's matchup will feature a battle of two complete opposites once the teams take the court.
The Sixers play at the NBA's highest pace (102.5 possessions per 48 minutes) and are sixth in points (104.2 points per game). That up-tempo style has also cost them on the defense end, as they allow the most points in the league at 110.8 points a night.
The Bobcats are anything but explosive in their approach on the floor. They rank 27th in pace (94.6 possessions per 48 minutes), are dead last in points per game with (88.8) and have scored 100 points just once this season.
Carter-Williams (knee) is out for Friday. He is officially listed as day to day.
Nerlens Noel (knee), Arnett Moultrie (ankle) and Jason Richardson (knee) are all out.
Kidd-Gilchrist (hand) and Brendan Haywood (foot) are out for the Bobcats.
5. This and that
• The Sixers' four overtime games are tied with Washington for the most in the NBA.
• The Bobcats have averaged 85 points per game in their last seven meetings against the Sixers.
• The Bobcats are last in the NBA in field-goal percentage (40.9) and three-point percentage (29.4).