CHARLOTTE, N.C. -- Cam Newton threw three touchdown passes and ran for another, and Carolina's defense sacked Eli Manning seven times as the Panthers handed Tom Coughlin his worst defeat as coach of the New York Giants, 38-0 Sunday.
It was the largest margin of victory in Panthers history, and might help save coach Ron Rivera's job following a 0-2 start.
The Panthers allowed Newton to run out of the read option, which helped open up an offense that had been mostly stagnant in losses to Seattle and Buffalo.
Newton had 223 yards passing and threw two touchdowns passes to Brandon LaFell and one to Ted Ginn Jr. He ran for 45 yards and his first TD of the season.
The Giants are in trouble: Of the 161 teams that have started the season 0-3 since 1978, only five made the NFL playoffs (see full recap).
Redskins drop to 0-3 with loss to Lions
LANDOVER, Md. -- The Detroit Lions took advantage of a pair of fourth-quarter bobbles, including one by Robert Griffin III, in a 27-20 win over the Washington Redskins on Sunday.
Matthew Stafford threw for 385 yards, and Calvin Johnson and Nate Burleson both had 100 yards receiving for the Lions, who are 2-1.
Detroit beat the Redskins on the road for the first time since 1939, a 21-game streak that comes to a halt as the second longest in NFL history.
The score was tied at 17 when Griffin fumbled at the end of a scramble. The Lions recovered and kicked the go-ahead field goal on their next drive.
The Redskins (0-3) then had a touchdown pass overturned when video replay showed that Aldrick Robinson lost control of the ball (see full recap).
Cowboys rip Rams behind Murray's big day
ARLINGTON, Texas -- DeMarco Murray found the perfect antidote for his recent malaise: the St. Louis Rams.
Murray rushed for 175 yards and a touchdown two years after torching St. Louis with a franchise record as a rookie, and Tony Romo threw for three scores in a 31-7 victory Sunday.
Murray's first 100-yard game in more than a year started with a 14-yard run on Dallas' first offensive play, and he had plenty of open space on a 36-yarder to start Dallas' second drive to a 10-lead late in the first quarter.
Sam Bradford, Murray's old college teammate at Oklahoma, didn't have nearly as much room to operate.
The Cowboys (2-1) sacked him four times in the first half and had six in total after St. Louis (1-2) hadn't allowed a sack in four games dating to last season. It was the longest streak for the Rams since John Hadl was under center for a division champion in 1973 (see full recap).