Daniel Ochefu added 12 points for Villanova (11-4, 2-0 Big East), which has won seven in a row.
South Florida (9-5, 0-2) got 12 points from Victor Rudd. The Bulls had won the four previous games between the programs, including all three last season.
Ryan Arcidiacono, the Big East Rookie of the Week, gave Villanova a 46-32 lead on his first basket of the game, a 3-pointer, midway through the second half. The freshman, averaging 13 points, finished with five points.
Pinkston's layup made it 48-32 one minute after Arcidiacono's basket.
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